说明： Liproxstatin-1是一种有效的ferroptosis抑制剂，IC50为22 nM。 应用： Liproxstatin-1 在细胞活力试验和脂质过氧化测定中用作细胞死亡抑制剂。 Information Liproxstatin-1 Liproxstatin-1 is a potent ferroptosis inhibitor with an IC50 of 22 nM. Targets ferroptosis (Cell-free assay) 22 nM In vitro Liproxstatin-1 is able to inhibit ferroptosis in the low nanomolar range and inhibit the growth of Gpx4 −/− cells with IC50 of 22 nM. Liproxstatin-1 (50 nM) completely prevents lipid peroxidation in Gpx4 −/− cells. Liproxstatin-1 (200 nM) protects against FINs, such as BSO (10 µM), erastin (1 µM) and RSL3 (0.5 µM), in a dose dependent manner, whereas it fails to rescue cell death induced by staurosporine (0.2 µM) and H 2 O 2 (200 µM). In vivo Liproxstatin-1 remarkably extends survival compared with the vehicle-treated group, delays ferroptosis in tubular cells, and mitigates tissue injury in ischaemia/reperfusion-induced liver injury. Cell Research(from reference) Cell lines：Gpx4 −/− cells Concentrations：~200 nM Incubation Time：~72 h