氯尼达明已用作： 糖酵解抑制剂，以研究其对肿瘤干细胞（CSC）中上皮间质转化（EMT）的影响 线粒体通透性转换（MPT）诱导药物，研究其对替莫唑胺耐药的恶性胶质瘤细胞株的影响 线粒体己糖激酶抑制剂，以测定人急性髓系白血病细胞中的活性氧（ROS） Lonidamine is an indazole compound that has been reported to inhibit angiogenic-related endothelial cell functions. This compound has been found to trigger apoptosis in endothelial cells and cause a decrease in proliferation, migration, invasion, and morphogenesis. The apoptotic effects of Lonidamine have been demonstrated to be due to Bax, Bid, caspase-3, and caspase-9 activation, as well as cytochrome c release. Futher studies show that Lonidamine prevents cellular energy metabolism via HXK (hexokinase) inhibition. This compound also blocks CFTR Cl- channels in vitro. It elicits cell apoptosis and blocks CFTR Cl- channel.