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Product introduction

Mubritinib (TAK 165)是一种有效的HER2/ErbB2抑制剂，IC50为6 nM；对EGFR， FGFR， PDGFR， JAK1， Src和Blk没有抑制活性。A selective, potent, and irreversible ErbB2 and EGFR inhibitor. Mubritinib (TAK-165) is a potent inhibitor of HER2/ErbB2 with IC50 of 6 nM; no activity to EGFR, FGFR, PDGFR, JAK1, Src and Blk. A selective, potent, and irreversible ErbB2 and EGFR inhibitor.

Specs ⸢ View details ⸥

Chinese name

木利替尼, 受体蛋白-酪氨酸激酶 erbB-2 抑制剂

English name

Mubritinib (TAK 165)

Chinese alias

木利替尼

English alias

CAS number

366017-09-6

molecular formula

C25H23F3N4O2

molecular weight

468.47 g/mol

Exact mass

PSA

66.000 Å²

Logp

5.4

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