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Product introduction

Information ML390 ML390 is a human DHODH inhibitor with an IC50 of 0.56 μM and induces differentiation in acute myeloid leukemia. Targets DHODH (Cell-free assay) 0.56 μM In vitro ML390 was active with an ED50 (effective concentration triggering 50% of its maximal differentiation activity) of 2 μM in murine and human AML cell lines, offering insight into the mechanism of overcoming differentiation arrest. DHODH inhibitors demonstrated effective at prolonging survival in animal models of leukemia. Cell Research(from reference) Cell lines：Lys-GFP-ER-HoxA9 cells Concentrations：10 μM Incubation Time：48 h

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Chinese name

ML390

English name

ML390

Chinese alias

English alias

N-(2-((R)-1,2,3,4-tetrahydronaphthalen-1-ylcarbamoyl)ethyl)-4-(trifluoromethoxy)benzamide | (R)-N-(3-oxo-3-((1,2,3,4-tetrahydronaphthalen-1-yl)amino)propyl)-4-(trifluoromethoxy)benzamide

CAS number

2029049-79-2

molecular formula

C21H21F3N2O3

molecular weight

406.4 g/mol

Exact mass

≥99%

PSA

67.400 Å²

Logp

5.065

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