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Product introduction

Product Introduction A cell-permeable pyrimido-isoquinolinone compound that acts as a potent, reversible, and ATP-competitive inhibitor of DNA-PK (IC50 = 280 nM) with ~19-fold selectivity over mTOR (IC50 = 5.3 µM). Exhibits much reduced or no activity against 43 other commonly studied kinases, including PI 3-K, ATM, and ATR. Shown to induce apoptosis and inhibit mTOR-dependent growth in TSC1-/- murine embryo fibroblasts.

Specs ⸢ View details ⸥

Chinese name

2-吗啉基-4H-嘧啶并[2,1-a]异喹啉-4-酮

English name

2-Morpholino-4H-pyrimido[2,1-a]isoquinolin-4-one

Chinese alias

化合物401 | 2-吗啉基-4H-嘧啶并[2,1-a]异喹啉-4-酮

English alias

CAS number

168425-64-7

molecular formula

C16H15N3O2

molecular weight

281.32 g/mol

Exact mass

10mM in DMSO

PSA

45.100 Å²

Logp

1.200

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