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Product introduction

Information MCU-i4 MCU-i4 is a negative modulator of the mitochondrial calcium uniporter (MCU) complex that directly binds a specific cleft in MICU1 and decreases mitochondrial Ca2+ influx. Targets MCU1 In vitro MCU-i4 decreases mitochondrial Ca2+ influx. Docking simulations reveal that MCU-i4 directly binds a specific cleft in MICU1, a key element of the MCU complex that controls channel gating. Accordingly, in MICU1-silenced or deleted cells, the inhibitory effect of MCU-i4 is lost. Moreover, MCU-i4 fails to inhibit mitochondrial Ca2+ uptake in cells expressing a MICU1 mutated in the critical amino acids that forge the predicted binding cleft. Cell Research(from reference) Cell lines：C2C12 myoblasts Concentrations：10 μM Incubation Time：24 h

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Chinese name

MCU-i4

English name

MCU-i4

Chinese alias

English alias

3-Quinolinecarboxylic acid,4-[[4-(diethylamino)phenyl]amino]-6-methyl-,ethyl ester

CAS number

371924-24-2

molecular formula

C23H27N3O2

molecular weight

377.48 g/mol

Exact mass

≥99%

PSA

54.500 Å²

Logp

5.700

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