Methylprednisolone aceponate (ZK 91588) is a glucocorticoid and anti-inflammatory agent with weak systemic effects. Methylprednisolone aceponate is a selective glucocorticoid receptor Ligand.Methylprednisolone aceponate can be used for research of eczema and other inflammatory skin disorders . In Vitro Methylprednisolone aceponate inhibits collagenase promoter activity (in HeLa cells), LPS-induced IL-12p40 secretion (in human PBMCs) and phytohemagglutinin-induced IFN-γ secretion (in human PBMCs) with IC 50 s of 9.3, 16.8, 15.2 nM. Methylprednisolone aceponate induces MMTV promoter and TAT activities with EC 50 s of 21.8 and 20.5 nM respectively. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo Methylprednisolone aceponate (topically applied, 50 μL,，Coroton oil-induced Evan blue edema) shows anti-inflammatory effect with an IC 50 of 0.0015%, with low systemic side effect . Methylprednisolone aceponate (0.0001%-0.1%, topically applied) inhibits oedema formation with ED 50 of 0.002% in irritant contact dermatitis in mice and rat. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Irritant contact dermatitis mice and ratDosage: 0.0001%-0.1% Administration: Topically applied, 10 µL for mice and 20 µL for rats. Result: Significantly inhibited ear inflammation.