Miclxin (DS37262926) is a potent inhibitor of mutant β-catenin , involving in Wnt signaling pathway. Miclxin induces β-catenin-dependent apoptosis , leads to severe mitochondrial damage with the loss of mitochondrial membrane. Miclxin kills tumor via targeting to MIC60 , a major components of the mitochondrial contact site and cristae organizing system (MICOS) complex. In Vitro Miclxin (0-15 μM; 48 h) inhibits the growth of β-catenin-mutated HCT116 cells and isogenic HCT116 (CTNNB1 Δ45/-) cells, and induces (10 μM; 24 h) apoptosis in HCT116 cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Viability AssayCell Line: HCT116 (CTNNB1 +/–) and (CTNNB1 △45/–) Concentration: 0, 5, 8, 10, 12, and 15 μM Incubation Time: 48 hours Result: Inhibited cell growth with inhibition rate of 100% at 15 μM. Form:Solid