- Toxicity summary： 3-甲基 -2-氧代戊酸由细胞质支链氨基转移酶 1 从亮氨酸产生，随后被支链酮酸脱氢酶 E1 进一步降解为 2-甲基 -1-羟基丁基-ThPP。它用作枫糖尿病（MSUD）的临床标记物。MSUD 是由于支链α-酮酸脱氢酶复合体缺乏引起的，导致支链氨基酸及其相应的α-酮酸和β-羟酸在血液、尿液和脑脊液中积累，造成神经损伤和精神发育迟缓。
- Regulatory information： 新西兰 EPA 化学品状态清单：α-酮β-甲基丁酸：没有单独的批准，但可以在适当的群体标准下使用
- Health Effects： 长期高水平的 3-甲基 -2-氧代戊酸与枫糖尿病（Maple Syrup Urine Disease）相关。
- Hazard categories and classifications： 眼刺激 2A (100%)
- Carcinogen Classification： 对人类无致癌性指示（IARC 未列入）。
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3-methyl-2-oxopentanoic acid 10mM in DMSO 1ml
Macklin 3-methyl-2-oxopentanoic acid 10mM in DMSO 1ml, CAS 1460-34-0, complete specifications; suitable for production, research, laboratory testing and inspection; digital one-stop procurement platform for scientific materials.
