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Product introduction
物理描述 | 吡拉明是一种粘性棕色液体。(NTP, 1992)
Chinese name
美吡拉敏
English name
N'-[(4-methoxyphenyl)methyl]-N,N-dimethyl-N'-pyridin-2-ylethane-1,2-diamine
Chinese alias
-
English alias
1,2-Ethanediamine,N-[(4-methoxyphenyl)methyl]-N',N'-dimethyl-N-2-pyridinyl- (9CI); Pyridine,2-[[2-(dimethylamino)ethyl](p-methoxybenzyl)amino]- (7CI,8CI); 2-[(2-Dimethylaminoethyl)(p-methoxybenzyl)amino]pyridine; Afko-Hist; Anhistabs; Anhistol; Antalergan
CAS number
91-84-9
molecular formula
C17H23N3O
molecular weight
285.4
Exact mass
-
PSA
28.6
Logp
3.3
Safety
  • Health hazard: 症状:接触此化合物可能导致嗜睡、中枢神经系统抑制和胃肠道紊乱。还可能导致口干、头痛、恶心、心动过速、尿潴留、神经紧张、定向障碍、蹒跚步态、幻觉、木僵、昏迷、肌张力亢进、震颤、兴奋、眼球震颤、高热、惊厥、粒细胞缺乏症和再生障碍性贫血。(NTP, 1992)
  • reactive group: 胺类、膦类和吡啶类
  • Disposal method: SRP:在审查时,土地处理或填埋(卫生填埋)处置实践的标准正在重大修订中。在实施废物残渣(包括废物污泥)的土地处置之前,咨询环境监管机构以获取可接受的处置实践指导。
  • First aid measures: 食入:不要催吐。如果受害者意识清醒且没有抽搐,给予1-2杯水稀释化学物质,并立即呼叫医院或中毒控制中心。如果医生建议,准备将受害者送往医院。如果受害者抽搐或昏迷,不要经口给予任何东西,确保受害者的气道通畅,让受害者侧卧,头部低于身体。不要催吐。立即将受害者送往医院。(NTP, 1992)
  • Regulatory information: REACH注册物质:状态:活跃 更新:28-02-2018 https://echa.europa.eu/registration-dossier/-/registered-dossier/22737
  • fire hazard: 该化学品的闪点数据不可用;但可能是可燃的。(NTP, 1992)
  • fire fighting: 涉及此材料的火灾可以用干化学灭火器、二氧化碳或哈龙灭火器控制。(NTP, 1992)
  • interaction: 与其他光敏药物同时使用/抗组胺药/可能导致光敏效应叠加。/抗组胺药/
  • reactivity profile: PYRILAMINE与酸中和形成盐和水,反应放热。可能与异氰酸酯、卤代有机物、过氧化物、酚类(酸性)、环氧乙烷、酸酐和酰卤不相容。与强还原剂(如氢化物)结合可能产生易燃的氢气。
  • Human toxicity extract: 尽管H1-阻断药相对具有较高的安全范围,但急性中毒很常见。...在儿童中,20到30片大多数市售抗组胺药片或胶囊代表致死或接近致死剂量。/抗组胺药/
  • Air and water reaction: 可能对光敏感。不溶于水。
  • Hazard categories and classifications: 致敏性 1 (88.6%)
  • Non-human toxic extract: ... 包括 ... 美吡拉明马来酸盐(Anthisan) ... 有不良副作用,但没有一种高度毒性。所有药物,但程度不同,均产生解痉和局部麻醉作用,并对心肌有抗颤动作用。某些抗组胺药的小剂量会引起抑郁、嗜睡、流涎和呕吐。静脉注射治疗剂量的美吡拉明可能导致马和牛出现短暂的神经症状,包括协调障碍和明显的视觉障碍。
  • Non-fire leakage response: 储存注意事项:应保护此材料免受光照,并将其存放在冰箱中。(NTP, 1992)
  • Personal protective equipment (PPE): 推荐呼吸器:在称量和稀释纯测试化学品时,佩戴NIOSH批准的半面罩呼吸器,配备有机蒸气/酸性气体 cartridges(专门用于有机蒸气、HCl、酸性气体和SO2)和粉尘/雾过滤器。(NTP,1992)
  • Antidote and first aid: 抗组胺药中毒无特异性疗法,治疗应遵循一般症状性和支持性原则。...如果呼吸衰竭,机械通气支持比使用容易引发或加重惊厥阶段的 analeptics 更安全、...有效。/抗组胺药/
  • Populations at Special Risk: 服用抗组胺药的老年患者可能更容易出现头晕、镇静、意识混乱和低血压。老年患者特别容易受到抗组胺药的抗胆碱副作用影响,如口干和尿潴留(尤其在男性中)。如果这些副作用发生并持续或严重,可能应停药。/抗组胺药/
  • Effects During Pregnancy and Lactation: 注射给药的相对高剂量抗组胺药可降低非哺乳期妇女和产后早期妇女的基础血清催乳素。然而,产后母亲使用抗组胺药预处理不影响哺乳引起的催乳素分泌。较低口服剂量的抗组胺药是否对血清催乳素有相同影响,或催乳素的变化对母乳喂养成功有任何后果尚未研究。已建立哺乳期的母亲的催乳素水平可能不会影响她的母乳喂养能力。
Technical Documents
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Related
upstream information
Manufacturing method:
二甲氨基乙基氯化物(CID:7901);对甲氧基苄基氯化物(CID:69993);氨基钠(CID:24533);氨基锂(CID:24532);马来酸(CID:444266)
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Mepyramine ≥99% 1mg

Mepyramine ≥99% 1mg Macklin 91-84-9, complete specifications, for production, research, laboratory testing and inspection, digital one-stop procurement platform for scientific materials.

item number:M993665-1mg
Product model:1mg
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