Nemifitide diTFA (INN 00835 diTFA) is a synthetic pentapeptide antidepressant with a potential for rapid onset of action. Nemifitide diTFA is a peptide analog of melanocyte-inhibiting factor (MIF) . Nemifitide diTFA can cross the blood-brain barrier . In Vitro Nemifitide diTFA (INN 00835 diTFA) and its active metabolite (M1) bind at micromolar concentrations to several receptors including the 5-HT 2A , 5-HT 2C , melanocortin MC4, MC5 and bombesin. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo Nemifitide diTFA (INN 00835 diTFA; 0.3 mg/kg; IP; daily; for 14 days) significantly increases swimming in the FSL rats after just 5 days of treatment and has long-lasting effect. Nemifitide diTFA (0.0125-15.0 mg/kg) significantly increases swimming in the FSL rats at both low (0.025-0.3 mg/kg) and high (3.0-15.0 mg/kg) doses but not at intermediate (0.4-2.4 mg/kg) doses. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Male Flinders Sensitive Line (FSL) rat weighing 280-320 gDosage: 0.3 mg/kg Administration: IP; daily; for 14 days Result: Significantly increased swimming in the FSL rats after just 5 days of treatment and had long-lasting effect. Form:Solid