Firsocostat (GS-0976, NDI-010976, ND-630)是acetyl CoA carboxylase (ACC)的一种可逆抑制剂，对hACC1和hACC2的IC50分别为2.1 nM，6.1 nM。 Information Firsocostat (GS-0976) Firsocostat (GS-0976, NDI-010976, ND-630) is a reversible inhibitor of acetyl CoA carboxylase (ACC) with IC50s of 2.1 nM,6.1 nM for hACC1 and hACC2,respectively. Targets hACC1 (Cell-free assay); hACC2 (Cell-free assay) 2.1 nM; 6.1 nM In vitro When ND-630 and [ 14 C]acetate were administered to Hep-G2 cells for 4 h, ND-630 inhibited FASyn with EC50 values of 66 nM in cells cultured in medium containing. When ND-630 and[ 14 C]palmitate were administered to C2C12 cells for 6 h, ND-630 increased both the release of [ 14 C]O 2 and the production of[ 14 C]acid-soluble material. In vivo When administered chronically to rats with diet-induced obesity, ND-630 reduces hepatic steatosis, improves insulin sensitivity, reduces weight gain without affecting food intake, and favorably affects dyslipidemia.