奥卡西平(oxc)是卡马西平的酮类似物。与卡马西平不同，奥卡西平没有副作用。它是一种抗癫痫药物，具有抗神经痛的特性。它比卡马西平具有药代动力学优势。它用于治疗神经性疼痛，并作为三叉神经痛的有效止痛药。OXC向其单羟基衍生物的分解代谢具有显著的药理特性。它调节钾通道和电压依赖性钠通道。oxc调节集合管中的v2受体-g蛋白复合物。 奥卡西平已被用于人类癫痫性脑内皮细胞的反相高效液相色谱分析中。 Oxcarbazepine (OXC) is the keto-analog of carbamazepine. Unlike carbamazepine, oxcarbazepine has no side effects. It is an antiepileptic drug, with an antineuralgic property. It has a pharmacokinetic advantage over carbamazepine. It is prescribed for neuropathic pain and serves as an effective pain reliever in trigeminal neuralgia.The catabolism of OXC to its monohydroxy derivative has significant pharmacologic property. It modulates potassium channels and voltage-dependent sodium channels. OXC modulates V2 receptor-G protein complex in collecting tubules and is used for treating diabetes insipidus. Oxcarbazepine (GP 47680) inhibits the binding of [3H]BTX to sodium channels with IC50 of 160 μM and also inhibits the influx of 22Na+ into rat brain synaptosomes with IC50 about 100 μM. Oxcarbazepine has been used in reversed-phase high-performance liquid chromatography of human epileptic brain endothelial cells.