
- Harmful effect: * 使用氧丁替林与其他抗胆碱能药物同时使用时应谨慎,因为它们可能导致不良反应风险增加,如口干(口腔干燥)、便秘和尿潴留。
- Toxicity summary: 据报道有2例药物过量病例是由于摄入100毫克奥昔布宁所致:1例涉及一名13岁男孩,另1例涉及一名34岁妇女。此外,还有另一份报告称同时饮酒与药物摄入。在另一病例中,一名4岁男孩在12小时内服用17毫克奥昔布宁后经历了药物过量和中枢抗胆碱综合征。上述所有病例的患者在接受医疗专业人员的支持性护理后完全康复。奥昔布宁的控释制剂含有不溶性内容物,可能导致胃结石的形成。
- Regulatory information: 新西兰化学品状态清单:奥昔布宁:没有单独批准,但可在适当的团体标准下使用
- Hepatotoxicity: 可能性评分:E(不太可能引起明显的肝损伤)。
- Human toxicity extract: 不良反应反映该药物的抗胆碱活性。口干最常见;恶心、视力模糊、潮红和心动过速也有报道。/氯化物/
- Hazard categories and classifications: 水生慢性3级(50%)
- Non-human toxic extract: 在清醒的狗中,0.10-10.0 MG/KG,静脉注射的效果是剂量相关的心动过速,舒张压轻微升高,收缩压无显著增加。在戊巴比妥麻醉下,压力反应相反,显示收缩压和舒张压降低。
- Drug Induced Liver Injury: 参考文献:DOI:10.1016/j.drudis.2019.09.022
- Effects During Pregnancy and Lactation: 抗胆碱药可抑制动物的泌乳,显然是通过抑制生长激素和催产素分泌。抗胆碱药也可降低非哺乳期妇女的血清催乳素。已建立泌乳的母亲,其催乳素水平可能不影响她母乳喂养的能力。制造商报告说,在上市后监测中,有报道称使用某些奥昔布宁(速释)制剂会导致泌乳抑制。
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Oxybutynin 10mM in DMSO 1ml
Oxybutynin 10mM in DMSO 1ml Macklin 5633-20-5, complete specifications, for production, research, laboratory testing and inspection, digital one-stop procurement platform for scientific materials.




