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Product introduction

PNU-74654是Wnt/β-catenin通路的的抑制剂，在NCI-H295 细胞中的IC50值为129.8 μM。 PNU-75654通过抑制β-catenin和Tcf4的相互作用（Kd=450 nM）,破坏Wnt 信号通路。 application： PNU-74654 has been used: as a β-catenin signaling inhibitor to study its effects on the funnel cartilage differentiation in Sepia sp. embryos as a Wnt signaling inhibitor to study its effects on glycogen synthase kinase 3β (GSK-3β) inhibition in prostate cancer cell lines as a Wnt signaling inhibitor to study its effects on leptin-induced cell proliferation in breast cancer cells

Specs ⸢ View details ⸥

Chinese name

PNU 74654

English name

PNU 74654

Chinese alias

2-苯氧基苯甲酸[(5-甲基-2-呋喃基)亚甲基]酰肼 | 苯甲酸,2-苯氧基-,2-[(5-甲基-2-呋喃基)亚甲基]酰胺

English alias

HMS3413P04 | HY-101130 | PNU74654 | PNU-74654 | J-003040 | NSC755984 | NSC-755984 | CCG-208115 | N-[(E)-(5-Methylfuran-2-yl)methylideneamino]-2-phenoxybenzamide | SCHEMBL3514174 | BDBM50436058 | AC-33054 | PNU 74654 | 2-Phenoxybenzoic acid-[(5-methyl-2-fu

CAS number

113906-27-7

molecular formula

C19H16N2O3

molecular weight

320.34 g/mol

Exact mass

10mM in DMSO

PSA

63.800 Å²

Logp

4.200

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