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Product introduction

Information Pibrentasvir (ABT-530) Pibrentasvir (ABT-530) is a novel and pan-genotypic hepatitis C virus (HCV) NS5A inhibitor with EC50 ranging from 1.4 pM to 5.0 pM against HCV replicons containing NS5A from genotypes 1 to 6. Targets GT5a (Cell-free assay); GT1a H77 (Cell-free assay); GT2b (Cell-free assay); GT4a (Cell-free assay); GT3a (Cell-free assay) 33615,1.4 pM(EC50); 1.8 pM(EC50); 1.9 pM(EC50); 1.9 pM(EC50); 2.1 pM(EC50) In vitro Pibrentasvir is a next-generation HCV NS5A inhibitor with potent and pan-genotypic activity, and it maintains activity against common amino acid substitutions of HCV genotypes 1 to 6 that are known to confer resistance to currently approved NS5A inhibitors. Cell Research(from reference) Cell lines：Huh-7 human hepatoma cell line, CEM-SS cells Incubation Time：6 days

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Chinese name

哌仑他韦(ABT-530), 非结构蛋白 5A 抑制剂

English name

Pibrentasvir (ABT-530)

Chinese alias

English alias

ABT 530 | D10816 | Dimethyl ((2S,2'S,3R,3'R)-((2S,2'S)-(((2R,5R)-1-(3,5-difluoro-4-(4-(4-fluorophenyl)piperidin-1-yl)phenyl)pyrrolidine-2,5-diyl)bis(5-fluoro-1H-benzo[d]imidazole-6,2-diyl))bis(pyrrolidine-2,1-diyl))bis(3-methoxy-1-oxobutane-1,2-diyl))dica

CAS number

1353900-92-1

molecular formula

C57H65F5N10O8

molecular weight

1113.18 g/mol

Exact mass

PSA

200.000 Å²

Logp

8.515

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