Panamesine (EMD 57445) is a sigma receptor ligand, which has a high affinity ( IC 50 6 nM) and selectivity for sigma binding sites. Panamesine is a potential atypical neuroleptic agent In Vivo Panamesine (EMD 57445; 0.3, 1, 3, 30 mg/kg) induces a dose-dependent increase of c-fos expression in several cortical areas with the strongest signals in the piriform cortex . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Female Sprague Dawley rats aged 2 months with a body weights of 200-250 g Dosage: 0.3, 1, 3, 30 mg/kg Administration: Subcutanous injections Result: Specific c-fos gene expression was detected at all concentrations (0.3 mg/kg, 1 mg/kg, 3 mg/kg, 30 mg/kg) tested in frontal, parietal, perirhinal, temporal, piriform, insular, limbic, cingulate and occipital cortex. Form:Solid IC50& Target:IC50: 6 nM (sigma receptor)