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和水剧烈反应。 格氏试剂通常以溶液的形式使用,一般呈现为浅灰色至浅棕色透明溶液。它们一般以烷基卤化镁(RMgX)和二烷基镁(R2Mg)的中间态存在,是和复杂组分形成的平衡态混合物 (称为“Schlenk平衡”)。 其中的一些种类可能由于溶解度降低而产生沉淀,但这并不会影响它们的实际使用。 当出现沉淀时,请轻轻地摇晃瓶子使悬浮物充分分散后使用(如果沉淀物的量非常少,您可以使用悬浮液的上层清液)。特别是在冬天等寒冷的条件下,可能经常生成大量沉淀物。这种情况下,请用干燥的玻璃棒捣碎后使用。另外,您也可以将瓶子放进塑料袋后浸入40℃的水浴中使固体溶解(加热需要专业人员来操作,以防有安全隐患,请注意瓶子开启时有机溶剂的挥发)。
Chinese name
苯基溴化镁
English name
Phenylmagnesium Bromide
Chinese alias
溴化苯基镁
English alias
DTXSID3059214 | Phenylmagnesium bromide 3M in Diethyl Ether | MFCD00000038 | phenyl magnesium bromide | magnesium;benzene;bromide | SCHEMBL5450 | CHEBI:51238 | Phenylmagnesium bromide, 1.0 M in THF | Bromophenylmagnesium | Phenylmagnesium bromide 1.0 M in
CAS number
100-58-3
molecular formula
C6H5BrMg
molecular weight
181.31 g/mol
Exact mass
1.0 M in THF
PSA
0.000 Ų
Logp
-
Safety
  • Fire Potential: Dangerous fire risk, solution highly flammable.
  • Adverse Effects: Dermatotoxin - Skin burns.
  • Hazards Summary: 3 molar solution in diethyl ether (CAS# 60-29-7): Reacts violently with water evolving flammable gases; May form explosive peroxides; Causes burns; [Alfa Aesar MSDS] See Methyl magnesium bromide, Cyclohexylmagnesium chloride, Phenylmagnesium chloride, and Ethyl magnesium bromide.
  • Disposal Methods: SRP: Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in air, soil or water; effects on animal, aquatic and plant life; and conformance with environmental and public health regulations. If it is possible or reasonable use an alternative chemical product with less inherent propensity for occupational harm/injury/toxicity or environmental contamination.
  • Toxicity Summary: IDENTIFICATION AND USE: Phenylmagnesium bromide is used for chemical Synthesis as Grignard reagent. HUMAN STUDIES: There are no data available. ANIMAL STUDIES: There are no data available.
  • Regulatory Information: New Zealand EPA Inventory of Chemical Status: Magnesium, bromophenyl-: Does not have an individual approval but may be used as a component in a product covered by a group standard. It is not approved for use as a chemical in its own right.
  • Hazard Classes and Categories: Skin Corr. 1B (100%)
  • Antidote and Emergency Treatment: /SRP:/ Advanced treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious, has severe pulmonary edema, or is in severe respiratory distress. Positive-pressure ventilation techniques with a bag valve mask device may be beneficial. Consider drug therapy for pulmonary edema ... . Consider administering a beta agonist such as albuterol for severe bronchospasm ... . Monitor cardiac rhythm and treat arrhythmias as necessary ... . Start IV administration of D5W TKO /SRP: "To keep open", minimal flow rate/. Use 0.9% saline (NS) or lactated Ringer's (LR) if signs of hypovolemia are present. For hypotension with signs of hypovolemia, administer fluid cautiously. Watch for signs of fluid overload ... . Treat seizures with diazepam or lorazepam...
  • Protective Action Criteria (PAC): PAC-3: 79 [mg/m3]
  • Military Exposure Guidelines (MEGs): collection=toxvaldb&kind=^MEG$
Related
upstream information
Methods of Manufacturing:
bromobenzene (CID:7961)
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phenylbromo magnesium 1. 0M solution in THF, MkSeal 100/ml

phenylbromo magnesium 1. 0M solution in THF, MkSeal 100/ml 100-58-3, , .

item number:P815567-100ml
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