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Product introduction

PF-03758309是PAK4的抑制剂，其IC50值为1.3 nM。 p21活化激酶（PAKs）属于丝氨酸/苏氨酸激酶家族，通过Rho GTP酶调节细胞骨架重组以及核信号。PAK4属于PAKs家族，特异性地与Cdc42-GTP和JNK-GTP相互作用。PAK4参与丝状伪足形成，在肌动蛋白细胞骨架重组中起着重要作用。生化研究表明，PF-3758309是ATP竞争性的PAK4抑制剂，可以抑制激酶活性。使用各种肿瘤细胞系筛选PAK4，PF-3758309抑制PAK4底物（GEF-H1）磷酸化和PAK4诱导的锚定非依赖性细胞生长，其IC50值分别为1.3 nM和4.7 ±3 nM。使用各种PAKs相关激酶筛选PF-3758309，PF-3758309对PAK4显示出良好效应及选择性。细胞分析表明，PF-3758309可以调节PAK4依赖性信号节点，并与p53信号通路相关。 PF-03758309 (PF-03758309) 是一种ATP竞争性的p21-activated kinase (PAK)抑制剂，其作用于PAK4的IC50为1.3 nM。PF-3758309 具有抗增殖的作用，在HCT116肿瘤模型中可诱导凋亡。

Specs ⸢ View details ⸥

Chinese name

PF-3758309, p21 (RAC1) 活化激酶 1 抑制剂

English name

PF-3758309

Chinese alias

English alias

7KC | PF03758309 pound>>PF 03758309 | Pyrrolo[3,4-c]pyrazole-5(1H)-carboxaMide, N-[(1S)-2-(diMethylaMino)-1-phenylethyl]-4,6-dihydro-6,6-diMethyl-3-[(2-Methylthieno[3,2-d]pyriMidin-4-yl)aMino]- | (S)-N-(2-(dimethylamino)-1-phenylethyl)-6,6-dimethyl-3-((2-

CAS number

898044-15-0

molecular formula

C25H30N8OS

molecular weight

490.62 g/mol

Exact mass

PSA

130.000 Å²

Logp

3.1

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PF-3758309 99% 5mg

Name: PF-3758309 99% 5mg
Brand: 麦克林
SKU: P872636-5mg

PF-3758309 99% 5mg CAS 898044-15-0, complete specifications for production, research, laboratory testing and inspection; digital one-stop procurement platform for scientific materials.

item number：P872636-5mg

Product model：5mg

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