帕米膦酸二钠盐是一种双膦酸盐钙代谢调节剂，可特异性诱导骨骼中钙的重吸收。此外，帕米膦酸选择性激活外周血单核细胞中的γδT细胞。替代研究表明，帕米膦酸二钠盐可促进成骨细胞增殖和分化，同时抑制破骨细胞生成和破骨细胞功能。此外，帕米膦酸通过抑制PC-3细胞中的uPA mRNA来下调尿激酶型纤溶酶原激活剂的表达。帕米膦酸二钠盐是FDPS（法呢基二磷酸合酶）的抑制剂。 Pamidronate, Disodium Salt is a bisphosphonate calcium metabolism regulator which specifically induces calcium reabsorption in bones. In addition, Pamidronate selectively activates γδTcells in peripheral blood mononuclear cells. Alternate studies indicate that Pamidronate, Disodium Salt promotes osteoblast proliferation and differentiation while inhibiting osteoclastogenesis and osteoclast function. Furthermore, Pamidronate down-regulates urokinase-type plasminogen activator expression by suppressing uPA mRNA in PC-3 cells. Pamidronate, Disodium Salt is an inhibitor of FDPS (farnesyl diphosphate synthase).