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Product introduction

Rocilinostat (ACY-1215)是一种选择性HDAC6抑制剂， IC50为5 nM，作用于HDAC6比作用于HDAC1/2/3(I型HDACs)选择性高10倍以上，对HDAC8具有微弱的作用活性，对HDAC4/5/7/9/11， Sirtuin1和Sirtuin2具有最低限度的作用活性。 Rocilinostat (ACY-1215) is a selective HDAC6 inhibitor with IC50 of 5 nM. It is >10-fold more selective for HDAC6 than HDAC1/2/3 (class I HDACs) with slight activity against HDAC8, minimal activity against HDAC4/5/7/9/11, Sirtuin1, and Sirtuin2.

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Chinese name

2-(二苯基氨基)-N-[7-(羟基氨基)-7-氧代庚基]-5-嘧啶甲酰胺, 组蛋白去乙酰化酶 6 抑制剂

English name

Rocilinostat (ACY-1215)

Chinese alias

English alias

CAS number

1316214-52-4

molecular formula

C24H27N5O3

molecular weight

433.5 g/mol

Exact mass

PSA

107.000 Å²

Logp

3.4

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