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Product introduction

Ruxolitinib (INCB018424)是第一个应用于临床的、有效的、选择性的JAK1/2抑制剂，IC50为3.3 nM/2.8 nM。作用于JAK1， JAK2与作用于JAK3相比，选择性强130倍多。An inhibitor of JAK1, JAK2, and JAK3. INCB018424 is the first potent, selective, JAK1/2 inhibitor to enter the clinic with IC50 of 3.3 nM/2.8 nM, >130-fold selectivity for JAK1/2 versus JAK3. An inhibitor of JAK1, JAK2, and JAK3.

Specs ⸢ View details ⸥

Chinese name

鲁索替尼 (INCB018424)

English name

Ruxolitinib (INCB018424)

Chinese alias

鲁索替尼 | 鲁索利替尼 | 卢索替尼 | 芦可替尼

English alias

CAS number

941678-49-5

molecular formula

C17H18N6

molecular weight

306.37 g/mol

Exact mass

PSA

83.200 Å²

Logp

2.100

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