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Product introduction

Rasagiline是一种选择性的、不可逆的MAO-B炔丙胺抑制剂，对MAO-B和MAO-A的IC50分别为4.43 nM和412 nM。甲磺酸雷沙吉兰可被用于MAO B型介导的细胞信号转导研究。 Rasagiline mesylate has been used: • to test its neuroprotective effects in retinitis pigmentosa (RP) by apoptosis regulator, Bax/Bcl-2 modulation • as monoamine oxidase-B inhibitor in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) induced mouse model • as an anti-parkinsonian agent to test its rescue functionality in 6-hydroxydopamine-lesioned zebrafish larvae towards bradykinetic and dyskinetic-like behavior.

Specs ⸢ View details ⸥

Chinese name

雷沙吉兰, 单胺氧化酶 B 抑制剂

English name

Rasagiline

Chinese alias

雷沙吉兰 | (R)-N-2-丙炔基-1-氢化茚胺甲磺酸盐甲磺酸酯, TVP-1012, 马来酸雷沙吉兰甲磺酸酯

English alias

CAS number

136236-51-6

molecular formula

C12H13N

molecular weight

171.24 g/mol

Exact mass

PSA

12.000 Å²

Logp

1.800

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