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Product introduction

R547是一种有效的，ATP竞争性CDK1/2/4抑制剂，Ki为2 nM/3 nM/1 nM，对CDK7和GSK3α/β作用效果稍弱，而抑制其他激酶活性。Phase 1。A selective inhibitor of cell cycle and transcriptional cyclin dependent kinases including Cdk1, Cdk2, and Cdk4. R547 is a potent ATP-competitive inhibitor of CDK1/2/4 with Ki of 2 nM/3 nM/1 nM. It is less potent to CDK7 and GSK3α/β, while inactive to other kinases. Phase 1. A selective inhibitor of cell cycle and transcriptional cyclin dependent kinases including Cdk1, Cdk2, and Cdk4.

Specs ⸢ View details ⸥

Chinese name

R547,cdk抑制剂, 细胞周期蛋白依赖性激酶 4 抑制剂

English name

R547

Chinese alias

English alias

(4-amino-2-(1-(methylsulfonyl)piperidin-4-ylamino)pyrimidin-5-yl)(2,3-difluoro-6-methoxyphenyl)methanone | (4-Amino-2-{[1-(Methylsulfonyl)piperidin-4-Yl]amino}pyrimidin-5-Yl)(2,3-Difluoro-6-Methoxyphenyl)methanone | R 547 | Ro 4584820 | SMR004701352 | NSC

CAS number

741713-40-6

molecular formula

C18H21F2N5O4S

molecular weight

441.45 g/mol

Exact mass

PSA

136.000 Å²

Logp

2.1

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R547 10mM in DMSO 1ml

Name: R547 10mM in DMSO 1ml
Brand: 麦克林
SKU: R797353-1ml

R547 10mM in DMSO 1ml Macklin 741713-40-6, complete specifications, for production, research, laboratory testing and inspection, digital one-stop procurement platform for scientific materials.

item number：R797353-1ml

Product model：1ml

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Lead Time：30days

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R547 10mM in DMSO 1ml

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