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Product introduction

JNJ-26854165 (Serdemetan)是一种HDM2泛素连接酶拮抗剂，作用于p53野生型细胞，诱导早期凋亡，在缺乏功能性p53的细胞中，抑制细胞增殖而延迟细胞凋亡。 JNJ-26854165 (Serdemetan) acts as a HDM2 ubiquitin ligase antagonist and also induces early apoptosis in p53 wild-type cells, inhibits cellular proliferation followed by delayed apoptosis in the absence of functional p53. A p53 activator and HDM2 ubiquitin ligase (MDM2) inhibitor

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Chinese name

JNJ-26854165 (Serdemetan)

English name

JNJ-26854165 (Serdemetan)

Chinese alias

JNJ-26854165（Serdemetan）

English alias

CCG-264846 | AS-56263 | NCGC00263171-01 | 2-(Furan-2-yl)thiazolidine-4-carboxylicacid | JNJ-26854165 (Serdemetan) | FT-0689750 | N1-(2-(1H-Indol-3-yl)ethyl)-N4-(pyridin-4-yl)benzene-1,4-diamine | PBANXRNIXGEHPZ-UHFFFAOYSA-N | JNJ 26854165 | BCP02124 | A86

CAS number

881202-45-5

molecular formula

C21H20N4

molecular weight

328.42 g/mol

Exact mass

≥98%

PSA

52.700 Å²

Logp

4.600

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