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Product introduction

Sorafenib是Raf-1, B-Raf和VEGFR-2的多重激酶抑制剂，IC50分别为6 nM, 22 nM和90 nM。还能抑制野生型和V599E突变型BRAF活性。 This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.An inhibitor of tyrosine protein kinases that targets the Raf/Mek/Erk pathway Sorafenib is a multikinase inhibitor of Raf-1, B-Raf and VEGFR-2 with IC50 of 6 nM, 22 nM and 90 nM, respectively.This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia. An inhibitor of tyrosine protein kinases that targets the Raf/Mek/Erk pathway

Specs ⸢ View details ⸥

Chinese name

索拉非尼, B-Raf 原癌基因丝氨酸/苏氨酸激酶的抑制剂

English name

Sorafenib

Chinese alias

English alias

4(4-{3-[4-Chloro-3-(trifluoromethyl)phenyl]ureido}phenoxy)-N(sup 2)-methylpyridine-2-carboxamide | SCHEMBL8218 | L01XE05 | NSC7177 | UNII-9ZOQ3TZI87 | NSC747971 | NSC-747971 | BAY 439006 | BAY 43-9006 | 4-[4-[[[[4-chloro-3-(trifluoromethyl)phenyl]amino]ca

CAS number

284461-73-0

molecular formula

C21H16ClF3N4O3

molecular weight

464.83 g/mol

Exact mass

PSA

92.400 Å²

Logp

4.100

Technical Documents

284461-73-0 | Sorafenib.pdf
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