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Product introduction

SEC inhibitor KL-1 (KL-1) 是一种有效的 super elongation complex (SEC) 的选择性抑制剂，可破坏SEC支架蛋白AFF4与P-TEFb之间的相互作用，从而导致自启动子近端暂停位点的Pol II释放受损和进行性转录延伸的平均速率的降低。KL-1 对AFF4-CCNT1相互作用起到剂量依赖性的抑制作用，其Ki值为3.48 μM。 Information SEC inhibitor KL-1 (KL-1) is a potent and selective inhibitor ofsuper elongation complex (SEC)that disrupts the interaction between the SEC scaffolding protein AFF4 and P-TEFb, resulting in impaired release of Pol II from promoter-proximal pause sites and a reduced average rate of processive transcription elongation. KL-1 exhibits an dose-dependent inhibitory effect on AFF4-CCNT1 interaction with Ki of 3.48 μM.

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Chinese name

SEC抑制剂KL-1

English name

SEC inhibitor KL-1

Chinese alias

English alias

CAS number

900308-84-1

molecular formula

C18H16ClNO4

molecular weight

345.78 g/mol

Exact mass

≥98%

PSA

Logp

3.545

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