蛇孢菌素A是植物病原性真菌产生的一类植物毒性代谢产物的主要成员。蛇孢菌素A在钙调节中起钙调蛋白作用的抑制剂的作用。微生物筛选技术公司的内部测试表明，蛇孢菌素A具有广泛的生物学特性，具有抗菌，抗真菌，抗肿瘤和杀线虫活性。蛇孢菌素A阻断钙调蛋白依赖性磷酸二酯酶的激活，IC50值为9μM。蛇孢菌素A通过与保守的赖氨酸残基共价结合来拮抗植物和动物的多种形式的钙调蛋白。 Ophiobolin A is the dominant member of a class of phytotoxic metabolites produced by plant pathogenic fungi. Ophiobolin A acts as an inhibitor of calmodulin action in calcium regulation. In-house testing at Microbial Screening Technologies has shown that Ophiobolin A possesses a broad biological profile with antibacterial, antifungal, antitumor and nematocidal activiites. Ophiobolin A blocks the activation of calmodulin-dependent phosphodiesterase with an IC50 value of 9 μM. Ophiobolin A antagonizes a variety of forms of calmodulin from plants and animals by binding covalently to conserved lysine residues.