OSMI-4 是一种低纳摩尔的O-连接的N-乙酰半乳糖胺转移酶 (OGT) 的抑制剂，其在细胞中的EC50 值为3 μM。 产品应用： OSMI-4 是一种 O-linked N-acetylglucosamine transferase (O-GlcNAc transferase, OGT) 的抑制剂，在细胞中的EC50值为3 μM。 Information OSMI-4 OSMI-4 is an inhibitor of O-GlcNAc transferase (OGT) with EC50 of 3 μM in cells. Targets OGT (Cell-free assay) 3 μM(EC50) In vitro OSMI-4 reduces O-GlcNAc levels almost completely by 5 μM. A decrease in HCF-1 cleavage products and the appearance of uncleaved HCF-1 is observed in cells treated with OSMI-4. OSMI-4 is a kind of structure-based evolution of small molecule OGT inhibitors with low nanomolar binding affinities. OSMI-4 exhibits a ~3 μM EC50 in cells, making it especially attractive for probing OGT’s complex biology. Cell Research(from reference) Cell lines：HEK293T cells Concentrations：5 μM, 10 μM, 20 μM Incubation Time：2 h, 8 h, 16 h, 24 h