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Product introduction
Edoxaban (DU-176b) 是factor Xa选择性抑制剂,也是抗凝药物。 作为一种关键的丝氨酸蛋白酶,Xa因子(FXa)是预防及治疗血栓栓塞性疾病的潜在靶酶。Edoxaban tosylate monohydrate是新型的能够直接抑制FXa活性的抗血栓药。 体外实验:Edoxaban tosylate monohydrate (DU-176b)抑制FXa,其对游离FXa和凝血酶原酶的Ki值分别为0.561 nM和2.98 nM,对FXa表现出超过10 000倍的选择性。DU-176b使人血浆中凝血酶原时间加倍,活化部分凝血酶原时间。DU-176b并不影响由ADP、胶原或U46619引起的血小板聚集。 体内试验:DU-176b剂量依赖性抑制大鼠和兔血栓形成模型中的血栓形成,虽然在抗血栓形成的剂量下大鼠的流血时间并没有显著延长。 临床试验:先前的研究证明了人口服[14C] Edoxaban后的物料平衡和药代动力学。物料平衡试验表明不变的Edoxaban是最主要的成分。Edoxaban会通过多种途径排出,但每种途径的排出量仅占总体排出量的一小部分.
Chinese name
依多沙班对甲苯磺酸盐一水合物
English name
Edoxaban tosylate Monohydrate
Chinese alias
-
English alias
N1-(5-chloropyridin-2-yl)-N2-((1S,2R,4S)-4-[(dimethylamino)carbonyl]-2-{[(5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridin-2-yl)carbonyl]amino}cyclohexyl)ethanediamide p-toluenesulfonic acid monohydrate | CCG-270422 | D09546 | N1-(5-Chloropyridin-2-yl)-N
CAS number
1229194-11-9
molecular formula
C31H40ClN7O8S2
molecular weight
738.3 g/mol
Exact mass
≥97%
PSA
229.000 Ų
Logp
-
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Research chemical 99% 5mg

Research chemical 99% 5mg, complete specifications; suitable for production, research, laboratory testing and inspection; digital one-stop procurement platform for scientific materials.

item number:S80198-5mg
Product model:5mg
level: 99% 5mg
Lead Time:30days
sold 652 Items
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