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Product introduction

TG101209是JAK2选择性抑制剂，IC50为6 nM，对Flt3和RET的IC50为25 nM和17 nM，比对JAK3的抑制性高30倍，对JAK2V617F和MPLW515L/K突变型敏感，还能抑制BRD4，IC50为130 nM。An inhibitor of JAK2, Flt-3, Ret, and JAK3 TG101209 is a selective JAK2 inhibitor with IC50 of 6 nM, less potent to Flt3 and RET with IC50 of 25 nM and 17 nM, ~30-fold selective for JAK2 than JAK3, sensitive to JAK2V617F and MPLW515L/K mutations; TG101209 inhibit BRD4 activity with IC50 of 130 nM. An inhibitor of JAK2, Flt-3, Ret, and JAK3

Specs ⸢ View details ⸥

Chinese name

TG101209

English name

TG101209

Chinese alias

N-(1,1-二甲基乙基)-3-[[5-甲基-2-[[4-(4-甲基-1-哌嗪基)苯基]氨基]-4-嘧啶基]氨基]苯磺酰胺

English alias

NCGC00262608-02 | AC-24600 | N-(tert-Butyl)-3-((5-methyl-2-((4-(4-methylpiperazin-1-yl)phenyl)amino)pyrimidin-4-yl)amino)benzenesulfonamide | Q27162453 | SW219632-1 | CCG-203019 | Kinome_702 | BCP02514 | CHEBI:90304 | CID 16722832 | N-tert-Butyl-3-({5-met

CAS number

936091-14-4

molecular formula

C26H35N7O2S

molecular weight

509.67 g/mol

Exact mass

≥98%

PSA

111.000 Å²

Logp

4.2

Technical Documents

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Research chemical 96% 5mg

Name: Research chemical 96% 5mg
Brand: MedMol
SKU: S81124-5mg

Research chemical 96% 5mg, complete specifications; suitable for production, research, laboratory testing and inspection; digital one-stop procurement platform for scientific materials.

item number：S81124-5mg

Product model：5mg

level： 96% 5mg

Lead Time：30days

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Research chemical 96% 5mg

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