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Product introduction
Quiflapon (MK-591)是一种选择性和特异性的 FLAP 抑制剂,IC50 为 1.6 nM。Quiflapon 也是一种有效的白三烯生物合成 (leukotriene biosynthesis) 抑制剂,在完整的人和诱导的大鼠多形核白细胞 PMNLs 中,其 IC50 值分别为 3.1 nM 和 6.1 nM。Quiflapon 可以诱导细胞凋亡 (apoptosis)。 MK-0591,一种MK-886类似物,是有效的和可口服的白三烯生物合成抑制剂,其IC50值为600 ng/ml。 MK-0591(250 mg)几乎完全抑制全血或活动性疾病患者中全身性白三烯合成(>90%),并诱导炎症靶组织合成LTB4。 MK-0591是一种治疗哮喘和炎症性肠病的潜在药物。MK-0591特异性地结合5-脂氧合酶(一种膜蛋白激活蛋白FLAP),两者的相互作用是炎性细胞合成LT的必要条件。 在全血以及BAL细胞中,MK-0591分别抑制了96%和91%的LTB4合成。与此相反,MK-0591不影响气道高反应性、臭氧引起的支气管收缩或嗜中性粒细胞向BAL细胞的流入。
Chinese name
喹夫拉朋
English name
MK-0591
Chinese alias
-
English alias
SB19076 | MK 0591 | 3-(tert-Butylthio)-1-(p-chlorobenzyl)-alpha,alpha-dimethyl-5-(2-quinolylmethoxy)indole-2-propionic acid | 3-[3-(tert-butylsulfanyl)-1-(4-chlorobenzyl)-5-(quinolin-2-ylmethoxy)-1H-indol-2-yl]-2,2-dimethylpropanoic acid | Quiflapon free
CAS number
136668-42-3
molecular formula
C34H35ClN2O3S
molecular weight
587.17 g/mol
Exact mass
≥98%
PSA
89.700 Ų
Logp
8.200
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Research chemical ≥98% 100mg

Research chemical ≥98% 100mg, complete specifications; suitable for production, research, laboratory testing and inspection; digital one-stop procurement platform for scientific materials.

item number:S83003-100mg
Product model:100mg
level: ≥98% 100mg
Lead Time:30days
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