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Product introduction
SPP-86 是一种选择性的 RET 酪氨酸激酶的有效抑制剂,其 IC50 值为 8 nM。SPP-86 抑制 MCF7 细胞中 RET 诱导激活的 PI3K/Akt 和 MAPK 信号通路,也能抑制 RET 诱导的 ERα 磷酸化。
Chinese name
SPP 86,RET抑制剂
English name
SPP 86
Chinese alias
1-(1-甲基乙基)-3-(2-苯基乙炔基)-1H-吡唑并[3,4-d]嘧啶-4-胺
English alias
SPP8 | 1-Isopropyl-3-(phenylethynyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine | 1-(1-Methylethyl)-3-(2-phenylethynyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine | SPP86
CAS number
1357349-91-7
molecular formula
C16H15N5
molecular weight
277.32 g/mol
Exact mass
≥98%(HPLC)
PSA
69.600 Ų
Logp
2.6
Technical Documents
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MedMol SPP-86 98% 5mg

MedMol SPP-86 98% 5mg, complete specifications; suitable for production, research, laboratory testing and inspection; digital one-stop procurement platform for scientific materials.

item number:S89397-5mg
Product model:5mg
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Lead Time:30days
sold 643 Items
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