Information NIK SMI1 NIK SMI1 is a highly potent and selective NF-κB-inducing kinase (NIK) inhibitor with Ki of 0.23 nM for NIK-catalyzed hydrolysis of ATP to ADP. Targets NIK-catalyzed hydrolysis of ATP to ADP 0.23 nM(Ki) In vitro NIK SMI1 exhibits selective inhibition of LTβR-dependent p52 translocation and transcription of NF-κB2 related genes. NIK SMI1 is shown to have a favorable pharmacokinetic profile across species and to inhibit BAFF-induced B cell survival in vitro. In vivo NIK SMI1 inhibits BAFF signaling and reduces splenic marginal zone B cells in vivo. Cell Research(from reference) Cell lines：293 cells, HeLa cells, SF9 cell line, Human B cells, Mouse B cells Concentrations：1 μM, different concentrations Incubation Time：24 h, 5 h