亚油酰甘氨酸是亚油酰甘氨酸亚油酰乙醇酰胺的内源同系物。花生四烯酸甘氨酸是在哺乳动物皮肤，脊髓和大脑中产生的花生四烯酸和甘氨酸的结合物，它是anandamide（AEA）的结构对应物，据报道在整个动物实验中具有镇痛作用。它对中央大麻素（CB1）受体的亲和力较弱，对G蛋白偶联受体GPR-18的亲和力高，并且受脂肪酸酰胺水解酶（FAAH）活性的代谢调控。亚油酰基甘氨酸抑制含有FAAH的N18TG2细胞膜（IC | 50 |〜25 µM）中AEA的水解，其效力低于花生四烯酸甘氨酸（IC | 50 | = 7 µM Linoleoyl glycine is an endogenous homolog of linoleoyl ethanolamide, an arachidonyl glycine. Arachidonyl glycine, the conjugate of arachidonic acid and glycine produced in mammalian skin, spinal cord and brain, is a structural counterpart of anandamide (AEA) that is reported to have analgesic activities in whole animal experiments. It has poor affinity for the central cannabinoid (CB1) receptor, high-affinity for the G protein-coupled receptor GPR-18, and is metabolically regulated by fatty acid amide hydrolase (FAAH) activity. Linoleoyl glycine inhibits the hydrolysis of AEA in FAAH-containing N18TG2 cell membranes (IC|50|~ 25 μM), which is less potent than that of arachidonyl glycine (IC|50|= 7 μM). The biological significance of linoleoyl glycine has not yet been determined.