硫代乙酸 (TAA) 可在新型亚磺酰基脲有机催化剂存在下，与硝基烯烃发生对映体选择性加成，形成手性 1，2-氨基硫醇衍生物。该方法已成功地用于抗真菌药物硫康唑的合成。 双官能团胺硫脲催化不对称 Michael 加成反应，生成硫酯。 不对称 1,6-共轭加成反应 对位 -醌甲烷在手性磷酸催化剂存在下生成手性含硫二苯基甲烷型化合物。 甲基丙烯酰胺与手性反式-2,5-二取代吡咯烷助剂的共轭加成形成手性 β-巯基羧酸衍生物。 硫代乙酸是将巯基引入有机分子的试剂。 Thioacetic acid is a reagent for introduction of the thiol group into organic molecules. A reagent for introduction of the thiol group into organic molecules. Thioacetic acid (TAA) can undergo: • Enantioselective addition to nitroalkenes to form chiral 1,2-aminothiol derivatives in the presence of a novel sulfinyl urea organocatalyst. This method has been successfully employed in the synthesis of antifungal drug, sulconazole. • Asymmetric Michael addition reaction with chalcones in the presence of a bifunctional amine thiourea catalyst to form synthetically useful thioesters. • Asymmetric 1,6-conjugate addition with para-quinone methides in the presence of a chiral phosphoric acid catalyst to form chiral sulfur-containing diphenylmethane-type compounds. • Conjugate addition to methacrylamides with chiral trans-2,5-disubstituted pyrrolidine auxiliaries to form chiral β-mercaptocarboxylic acid derivatives. Thioacetic acid is a reagent for introduction of the thiol group into organic molecules. A reagent for introduction of the thiol group into organic molecules.