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Product introduction

TCS 21311 (NIBR3049) 是一种有效的高选择性 JAK3 抑制剂，其 IC50 为 8 nM，它的选择性是 JAK1，JAK2 和 TYK2 的100倍以上。TCS 21311 (NIBR3049) 抑制 PKCα，PKCθ 和 GSK3β，IC50 值分别为 13、68 和 3 nM。 TCS 21311 (NIBR3049) is a potent, highly selective JAK3 inhibitor with an IC50 of 8 nM, it displays >100-fold selectivity over JAK1, JAK2 and TYK2. TCS 21311 (NIBR3049) inhibits PKCα, PKCθ, and GSK3β with IC50s of 13, 68, and 3 nM, respectively.

Specs ⸢ View details ⸥

Chinese name

TCS 21311,JAK3抑制剂

English name

TCS 21311

Chinese alias

3-[5-[4-(2-羟基-2-甲基-1-氧丙基)-1-哌嗪基] -2-(三氟甲基)苯基] -4-(1H-吲哚-3-基)-1H-吡咯-2,5-二酮

English alias

CAS number

1260181-14-3

molecular formula

C27H25F3N4O4

molecular weight

526.51 g/mol

Exact mass

PSA

106.000 Å²

Logp

2.900

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