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Product introduction

TL12-186 是一种依赖于 Cereblon 的多激酶 PROTAC 降解剂。包括 CDK，BTK，FLT3，Aurora激酶，TEC，ULK，ITK 等。TL12-186 抑制 CDK2/cyclin A 和 CDK9/cyclin T1，IC50 分别为 73 和 55 nM。

Specs ⸢ View details ⸥

Chinese name

TL 12-186,多激酶降解PROTAC, 大脑

English name

TL 12-186

Chinese alias

N-(2-(2-(2-(4-(4-((5-5-氯-4-((2-(异丙基磺酰基)苯基)氨基)嘧啶-2-基)氨基)苯基)哌嗪-1-yl)ethoxy)ethoxy)ethyl)-2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)acetamide

English alias

N-(2-(2-(2-(4-(4-((5-Chloro-4-((2-(isopropylsulfonyl)phenyl)amino)pyrimidin-2-yl)amino)phenyl)piperazin-1-yl)ethoxy)ethoxy)ethyl)-2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)acetamide

CAS number

2250025-88-6

molecular formula

C44H51ClN10O9S

molecular weight

931.46 g/mol

Exact mass

PSA

242.000 Å²

Logp

4.600

Technical Documents

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Consultation

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Research chemical 10mg; ≥98%; HPLC

Name: Research chemical 10mg; ≥98%; HPLC
Brand: 阿拉丁
SKU: T288251-10mg

Research chemical 10mg; ≥98%; HPLC; supplied for laboratory research, analysis, inspection, and scientific procurement use; specifications: 10mg; ≥98%; HPLC.

item number：T288251-10mg

Product model：10mg

level： 10mg; ≥98%; HPLC

Lead Time：30days

sold 471 Items

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Specifications：

10mg

Qty

Research chemical 10mg; ≥98%; HPLC

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