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Product introduction

TP-064 是一种有效的选择性蛋白精氨酸甲基转移酶 4 (PRMT4; CARM1) 抑制剂 (IC50 Application: TP 064 is a potent and selective PRMT4 inhibitor; inhibits methylation of H3 (1-25) and MED12 (IC50 values are 100-fold selectivity over other histone methyltransferases and non-epigenetic targets. Inhibits proliferation of certain multiple myeloma cell lines, arresting cells in G1 phase. TP 064 can be used in vivo. TP 064 inhibits the monocyte/macrophage-driven inflammation in ex vivo.

Specs ⸢ View details ⸥

Chinese name

TP 064,PRMT 4抑制剂

English name

TP 064

Chinese alias

N-甲基-N-(((2-(1-(2-(甲基氨基)乙基)哌啶-4-基)吡啶-4-基)甲基)-3-苯氧基苯甲酰胺

English alias

N-Methyl-N-((2-(1-(2-(methylamino)ethyl)piperidin-4-yl)pyridin-4-yl)methyl)-3-phenoxybenzamide

CAS number

2080306-20-1

molecular formula

C28H34N4O2

molecular weight

458.6 g/mol

Exact mass

PSA

57.700 Å²

Logp

3.500

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