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Product introduction

Tandutinib (MLN518)是一种有效的FLT3拮抗剂，IC50为0.22 μM，同时也抑制PDGFR和c-Kit，对FLT3作用效果比CSF-1R强15到20倍，比FGFR， EGFR和KDR等强100倍以上A piperazinyl quinazoline receptor tyrosine kinase inhibitor Tandutinib (MLN518, CT53518) is a potent FLT3 antagonist with IC50 of 0.22 μM, also inhibits PDGFR and c-Kit, 15 to 20-fold higher potency for FLT3 versus CSF-1R and >100-fold selectivity for the same target versus FGFR, EGFR and KDR. A piperazinyl quinazoline receptor tyrosine kinase inhibitor

Specs ⸢ View details ⸥

Chinese name

坦度替尼 (MLN518), 血小板衍生生长因子受体 beta 抑制剂

English name

Tandutinib (MLN518)

Chinese alias

坦度替尼

English alias

CAS number

387867-13-2

molecular formula

C31H42N6O4

molecular weight

562.72 g/mol

Exact mass

PSA

92.300 Å²

Logp

4.6

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