酸官能化的环辛炔衍生物。环辛炔可用于应变促进的无铜叠氮化物-炔烃点击化学反应。该氮杂二苯并环辛炔可与叠氮官能化化合物或生物分子发生反应，而不需要Cu(I) 催化剂以产生稳定的三唑键。 应用 二苯并环辛炔酸可用于八臂聚（乙二醇）的表面改性，使易于与PEG-双叠氮化物应变促进炔-叠氮化物环加合（SPAAC），以导致水凝胶的形成。这些水凝胶可用于蛋白质固定。 Acid functionalized cyclooctyne derivative. Cyclooctynes are useful in strain-promoted copper-free azide-alkyne click chemistry reactions. This azadibenzocyclooctyne will react with azide functionalized compounds or biomolecules without the need for a Cu(I) catalyst to result in a stable triazole linkage.Dibenzocyclooctyne-acid may be used for the surface modification of eight-arm poly(ethylene glycol), to make it susceptible to strain promoted alkyne-azide cycloaddition (SPAAC) with PEG-bis-azide leading to the formation of hydrogels. These hydrogels are useful for protein immobilization.