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Product introduction
丙酰奋乃静是吩噻嗪类化合物,是10H-吩噻嗪在氮原子处被2-(二甲基氨基)丙基取代,在2号位置被丙酰基取代的化合物。它具有镇静剂、吩噻嗪类抗精神病药物、组胺拮抗剂、血清素拮抗剂、多巴胺拮抗剂和毒蕈碱拮抗剂的作用。它是吩噻嗪类、叔胺化合物和芳香酮。它源自10H-吩噻嗪的氢化物。
Chinese name
丙酰马嗪
English name
1-[10-[2-(dimethylamino)propyl]phenothiazin-2-yl]propan-1-one
Chinese alias
丙酰异丙嗪 | 1-[10-[2-(二甲基氨基)丙基]苯并噻嗪-2-基]-1-丙酮
English alias
1-[10-[2-(Dimethylamino)propyl]phenothiazin-2-yl-1-propanone | 1-[10-[2-(Dimethylamino)propyl]phenothiazin-2-yl]-1-propanone | Propionylpromethazine | Wy 1359 | 2- Propionyl-10-[2-(dimethylamino)propyl]phenothiazine
CAS number
362-29-8
molecular formula
C20H24N2OS
molecular weight
340.5
Exact mass
-
PSA
48.9
Logp
4.8
Safety
  • Toxicity summary: 丙哌嗪是1型、2型和4型多巴胺受体、血清素(5-HT)受体2A和2C型、毒蕈碱受体1至5型、α(1)-受体和组胺H1-受体的拮抗剂。其主要用作镇静剂是由于其抗组胺作用。
  • interaction: 先前单独给予东莨菪碱或联合给予美哌啶和丙嗪的17名产妇给予了毒扁豆碱,以确定其对逆转胎儿心率变异性丧失的影响。在使用美哌啶和丙嗪联合治疗时,10名患者出现了逆转。
  • Health Effects: 它们会导致言语不清、定向障碍和"醉酒"行为。它们具有生理和心理成瘾性。
  • Symptoms and Signs: 罕见但严重的副作用包括惊厥(癫痫);呼吸困难或呼吸过快;心跳或脉搏快速或不规则;发热(高烧);血压高或低;膀胱控制丧失;肌肉僵硬(严重);出汗异常增加;皮肤异常苍白;以及异常疲劳或虚弱。
  • Hazard categories and classifications: 水环境慢性2(100%)
  • Carcinogen Classification: 对人类无致癌性迹象(未被IARC列出)。
Technical Documents
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upstream information
Manufacturing method:
氨基钠(CID:24533);丙嗪(CID:4940);氯化氢(CID:313)
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1-[10-[2-(Dimethylamino)propyl]phenothiazin-2-yl-1-propanone 95% 50mg

Yuanye 1-[10-[2-(Dimethylamino)propyl]phenothiazin-2-yl-1-propanone 95% 50mg, CAS 362-29-8, complete specifications; suitable for production, research, laboratory testing and inspection; digital one-stop procurement platform for scientific materials.

item number:T58194-50mg
Product model:50mg
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Lead Time:30days
sold 206 Items
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