氟前列腺素是一种PGF |2α| R（前列腺素F（FP）受体）激动剂，比PGF |2α|更具选择性。该化合物可以激活大鼠主动脉中ERK 2（细胞外信号调节激酶（ERK）），p38-丝裂原活化蛋白激酶（MAPK）和JNK | 3 |（c-Jun N端激酶（JNK））的磷酸化。研究表明，它可以通过抑制内皮素（ET）-1依赖性而改善通过小梁网（TM）的房水流出，从而诱导人肌细胞中的磷脂酶C和Ca | + |动员，并降低眼内压（IOP）。机制。氟前列腺素还抑制3T3-L1细胞中成脂基因的表达。 Fluprostenol is a PGF|2α|R (prostaglandin F (FP) receptor) agonist that is more selective than PGF|2α|. The compound can activate phosphorylation of ERK 2 (extracellular signal-regulated kinase (ERK)), p38-Mitogen-activated protein kinase (MAPK) and JNK|3|(c-Jun N-terminal kinase (JNK)) in rat aortas. Studies have shown that it can induce phospholipase C and Ca|+|mobilization in human myometrial cells and can decrease intraocular pressure (IOP) by improving aqueous humor outflow through the trabecular meshwork (TM) via inhibition of endothelin (ET)-1-dependent mechanisms. Fluprostenol also suppresses the expression of adipogenic genes in 3T3-L1 cells.