FSCPX is a potent and selective irreversible antagonist of A 1 adenosine receptor (A 1 AR) , with low nanomolar potency for binding to the A 1 AR. FSCPX could modify the effect of NBTI, a nucleoside transport inhibitor, by reducing the interstitial adenosine level in the guinea pig atrium In Vitro FSCPX irreversibly blocks the binding of [ 3 H]-8-cyclopentyl-1,3dipropylxanthine ([ 3 H]DPCPX), with an IC 50 of 11.8±3.2 nM in DDT 1 MF2 cells. FSCPX (20 μM; 48 h) attenuates protection from necrosis and apoptosis in A1AR-overexpressing LLC-PK1 cells. FSCPX (2-20 μM; 48 h) reverses the upregulation of HSP27 mRNA and protein in A1AR-overexpressing LLC-PK1 cells without an effect on the mRNA or protein for HSP70. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:A1AR