Tabersonine hydrochloride 是一种主要从蔷薇中分离出的吲哚类生物碱。Tabersonine 能破坏 Aβ(1-42) 的聚合和改善 Aβ 聚集诱导的细胞毒性。Tabersonine hydrochloride 具有抗炎活性，可用于 ALI/ARDS 的研究。 Information Tabersonine hydrochloride Tabersonine, an ingredient extracted from the bean of Voacanga africana, is a potent inhibitor against Aβ(1−42) aggregation and toxicity. Targets Aβ(1−42) aggregation In vitro Tabersonine disrupts Aβ(1−42) aggregation and ameliorates Aβ aggregate-induced cytotoxicity. It binds to Aβ(1−42) oligomers more strongly than to Aβ(1−42) monomers with Kd values of 69 μM and 535 μM, respectively. In vivo The biocompatibility and small size essential for permeating the blood−brain barrier make tabersonine a potential therapeutic drug candidate for treating Alzheimer\'s disease (AD). Cell Research(from reference) Cell lines：SH-SY5Y cell Concentrations：10 μM Incubation Time：24 h