Sangivamycin 是一种对人巨细胞病毒（HCMV）具有活性的细胞毒性嘌呤核苷。桑奇霉素也是一种选择性有效的PKC（蛋白激酶C）抑制剂（IC | 50 | =10μM）。该抑制作用相对于ATP是竞争性的，而相对于组蛋白和脂质辅因子而言是非竞争性的。组蛋白H1蛋白的磷酸化是桑奇霉素防止细胞生长并充当针对多种人类癌症的细胞毒剂的机制。 Sangivamycin 是一种核苷类似物，是蛋白激酶C (PKC) 的有效抑制剂，Ki 为 10 μM。Sangivamycin 对多种人类癌症具有有效的抗增殖活性。 Sangivamycin is a cytotoxic purine nucleoside active against human cytomegalovirus (HCMV). Sangivamycin is also a selective and potent PKC (protein kinase C) inhibitor (IC|50|= 10μM). The inhibition is competitive with respect to ATP and non-competitive with respect to histone and lipid cofactors. The phosphorylation of histone H1 protein is a mechanism by which Sangivamycin prevents the cell growth and acts as cytotoxic agent against a variety of human cancers. Product description Sangivamycin, a nucleoside analog, is a potent inhibitor of protein kinase C (PKC) with an Ki of 10 μM. Sangivamycin has potent antiproliferative activity against a variety of human cancers.