H-Tyr-Tyr-OH (L-Tyrosyl-L-tyrosine) is an antihypertensive peptide. H-Tyr-Tyr-OH inhibits angiotensin I-converting enzyme ( ACE ) with an IC 50 value of 0.028 mg/mL. H-Tyr-Tyr-OH can be used for the research of high blood pressure In Vitro H-Tyr-Tyr-OH shows inhibitory effect against ACE with an IC 50 value of 0.028 mg/mL. MCE has not independently confirmed the accuracy of these methods. They are for reference only. In Vivo H-Tyr-Tyr-OH (12.5 mg/kg; intraarterial injection once) effects systolic blood pressure in vivo . H-Tyr-Tyr-OH (0-100 mg/kg; i.p. once) effects blood pressure of spontaneously hypertensive rats . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Anesthetized male SpragueDawley rats Dosage: 12.5 mg/kg Administration: Intraarterial injection; 12.5 mg/kg once Result: Significantly elevated systolic blood pressure, with a peak increase of 5 min after administration. Animal Model: Spontaneously hypertensive rats Dosage: 0, 50 and 100 mg/kg Administration: Intraperitoneal injection; once Result: Significantly reduced blood pressure of spontaneously hypertensive rats, even at a dose of 50 mg/kg. Form:Solid IC50& Target:IC50: 0.028 mg/mL (ACE)