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Product introduction

产品介绍： UNC1215是L3MBTL3的有效的抑制剂，其对L3MBTL3的抑制强度比MBT家族其他成员更强。HEK293细胞转染了L3MBTL3的3 MBT区域的GFP融合蛋白后，用UNC1215处理可以减少剂量依赖性的反应时间通过结合和与L3MBTL3的共定位。通过AlphaScreen○R甲基化组蛋白肽竞争分析，UNC1215对L3MBTL3显示出较高的拮抗能力，IC50值为24±7.6 nM。作为甲基赖氨酸阅读蛋白L3MBTL3的第一个有效的，选择性的抑制剂，UNC1215通过拮抗L3MBTL3单或双甲基赖氨酸阅读功能显示出高度选择性。 UNC1215 is a potent and selective MBT (malignant brain tumor) antagonist, which binds L3MBTL3 with IC50 of 40 nM and Kd of 120 nM, 50-fold selective versus other members of the human MBT family.

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Chinese name

UNC1215,L3MBTL3 甲基赖氨酸结构域的拮抗剂, L3MBTL 组蛋白甲基赖氨酸结合蛋白 3 的激动剂

English name

UNC1215

Chinese alias

English alias

BP-21087 | GTPL8232 | SB19337 | AS-16797 | UNC1215, >=98% (HPLC) | 2-Phenylamino-1,4-bis(4-(pyrrolidinyl)piperidinyl)benzamide | UNC1215 | UNC-1215 | Butanoic acid, 2-amino-4-(methylsulfonyl)-, (.+/-.)- | EX-A193 | CCG-269911 | MFCD22683289 | HMS3426E15 |

CAS number

1415800-43-9

molecular formula

C32H43N5O2

molecular weight

529.72 g/mol

Exact mass

PSA

59.100 Å²

Logp

5.100

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UNC1215 10mM in DMSO 1ml

Name: UNC1215 10mM in DMSO 1ml
Brand: 麦克林
SKU: U797366-1ml

UNC1215 10mM in DMSO 1ml Macklin 1415800-43-9, complete specifications, for production, research, laboratory testing and inspection, digital one-stop procurement platform for scientific materials.

item number：U797366-1ml

Product model：1ml

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Lead Time：30days

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UNC1215 10mM in DMSO 1ml

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