Oxaliplatin (L-OHP) 是一种 DNA 烷化剂，一种 DNA 合成抑制剂。Oxaliplatin 会导致 DNA 交联损伤，阻止 DNA 复制和转录并导致细胞死亡。Oxaliplatin 可以诱导细胞自噬。 应用： 奥沙利铂已被用于：通过细胞活力测定，作为结肠直肠腺癌 SW480 细胞中的化学治疗剂；用于通过 MTT 比色法监测肝细胞癌 HepG2 和 HepG2/R 细胞中的细胞存活率；确定对人乳腺癌 MDA-MB-231 细胞的生长抑制作用。 Oxaliplatin is a second generation potent platinum-based anti-neoplastic agent that is believed to form inter- and intrastrand DNA adducts which activate signaling pathways culminating in apoptosis. The development of Oxaliplatin was inspired from the efficacy of its progenitor, Cisplatin , the first of this class of anti-neoplastic agents. Oxaliplatin displays higher cytotoxicity and lower nephrotoxicity than Cisplatin or Carboplatin , and shows antitumor activity in cell lines with acquired Cisplatin resistance. The enhanced activity of Oxaliplatin compared to other members of this class is attributed to the bulky diaminocyclohexane ligand in the major groove that might limit the flexibility of the Oxaliplatin-DNA adduct, and interfere with DNA repair enzymes differently. A potent anti-neoplastic agent that binds to DNA and shows efficacy in Cisplatin resistant cell lines Product class hAPIs, Metal based hAPIs Chemical properties Chemical formula C 8 H 14 N 2 O 4 Pt Empirical formula [Pt((R,R)-dach)(ox)] Molecular weight 397.28 Metal Pt Theoretical metal content 49 Physical state powder Color white