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Product introduction

Galicaftor (ABBV-2222; GLPG-2222) 是一种有效的，具有口服活性的囊性纤维化跨膜电导调节剂 (CFTR) 校正剂，可用于囊性纤维化的研究 Information Galicaftor (ABBV-2222) Galicaftor (ABBV-2222, GLPG2222) is a potent corrector of CFTR for the treatment of Cystic Fibrosis (CF). Targets CFTR In vitro ABBV-2222/GLPG2222 exhibits potent in vitro functional activity in primary patient cells harboring F508del/F508del CFTR with an EC50 Cell Research(from reference) Cell lines：CFBE41o-F508del CFTR-HRP cells Concentrations：0 - 20 μM Incubation Time：18-24 h

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Chinese name

加利卡弗特（ABBV-2222）, 囊性纤维化跨膜传导调节器正调节器

English name

Galicaftor (ABBV-2222)

Chinese alias

English alias

4-((2R,4R)-4-(((1-(2,2-DIFLUORO-1,3-BENZODIOXOL-5-YL)CYCLOPROPYL)CARBONYL)AMINO)-7-(DIFLUOROMETHOXY)-3,4-DIHYDRO-2H-CHROMEN-2-YL)BENZOIC ACID | AKOS040745007 | J0IIT8QSQS | 4-[(2R,4R)-4-[1-(2,2-difluoro-2H-1,3-benzodioxol-5-yl)cyclopropaneamido]-7-(difluo

CAS number

1918143-53-9

molecular formula

C28H21F4NO7

molecular weight

559.46 g/mol

Exact mass

≥98%

PSA

103.000 Å²

Logp

5.7

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